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(3) Different pharmacological effects of macrolides on airway epithelial barrier may be related to the difference of structural characteristics, which requires molecular docking and structure modeling methods to further clarify the underlying mechanisms

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A schematic model illustrating how GPR15 differentially regulates the effects of cigarette smoke exposure on CD and UC In TNBS-induced CD-like colitis, cigarette smoke exposure upregulates GPR15 expression on T cells, driving their differentiation into Th17 cells and exacerbating disease progression